For more information on the possible side effects of fenofibrate, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist. If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:. Fenofibrate oral tablet can interact with several other medications.
Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects. Below is a list of medications that can interact with fenofibrate. This list does not contain all drugs that may interact with fenofibrate. Before taking fenofibrate, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.
Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Taking it with fenofibrate raises your risk of bleeding. If you take these drugs together, your doctor may do blood tests more often or change your dosage of warfarin. Taking fenofibrate with certain cholesterol drugs called bile acid sequestrants may make it harder for your body to absorb fenofibrate. To prevent this, you should take fenofibrate 1 hour before taking the bile acid sequestrant, or 4—6 hours after taking it.
Examples of bile acid sequestrants include:. Also, taking fenofibrate with cholesterol drugs called statins raises your risk of rhabdomyolysis.
This is a serious condition that breaks down muscle. Examples of statin drugs include:. Taking fenofibrate with certain diabetes drugs called sulfonylureas raises your risk of low blood sugar. Examples of these drugs include:. Colchicine is a drug used to treat gout.
Taking it with fenofibrate raises your risk of muscle pain. This raises your risk of side effects from fenofibrate. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
This medication has not been studied in children. It should not be used in people younger than 18 years. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs, including fenofibrate, more slowly.
As a result, a higher amount of a drug stays in your body for a longer time. This increases your risk of side effects. Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body. For people with kidney disease: If you have mild kidney disease, you may need a lower dose of fenofibrate. This drug raises your risk of muscle pain and a serious muscle problem called rhabdomyolysis.
The risk is higher if you take the drug along with statins. Fenofibrate can cause abnormal results in tests of liver function. These abnormal results can indicate liver damage. This drug can also cause other liver damage and inflammation after years of use. Fenofibrate raises your risk of gallstones. Fenofibrate raises your risk of pancreatitis inflammation of the pancreas. Fenofibrate can cause severe allergic reactions. These can include anaphylaxis and angioedema swelling , and can be life-threatening.
These include Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Taking it again could be fatal cause death. For people with liver disease: Fenofibrate can cause liver problems, which could lead to liver failure.
Let your doctor know if you have a history of liver disease. Your doctor can tell you if fenofibrate is safe for you. If you have active liver disease, you should not take fenofibrate. For people with kidney disease: Fenofibrate may cause abnormal results from tests of kidney function. Do not use more of it, do not use it more often, or do not use it for a longer time than your doctor ordered.
In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's order about any special diet. If you have excess body weight, your doctor may tell you to exercise to lose this weight before using this medicine. Also avoid drinking alcohol before and during treatment with fenofibrate.
This medicine is usually taken once a day. Take the medicine at the same time each day to maintain the medication's effect. Do not open, crush, break, chew, or dissolve them. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Currently Enrolling Trials Show More. General Information Tricor fenofibrate is a peroxisome proliferator-activated receptor PPAR alpha agonist Tricor tablets are indicated as an adjunct to diet: To reduce elevated LDL-C, Total-C, TG and Apo B, and to increase HDLC in adult patients with primary hypercholesterolemia or mixed dyslipidemia For treatment of adult patients with severe hypertriglyceridemia Tricor tablets may be taken without regard to meals.
The recommended dosing is as follows: Primary hypercholesterolemia or mixed dyslipidemia: Initial dose of mg once daily Severe hypertriglyceridemia: Initial dose of 48 to mg once daily. Maximum dose is mg Renally impaired patients: Initial dose of 48 mg once daily Geriatric patients: Select the dose on the basis of renal function Mechanism of Action Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein VLDL in treated patients.
Side Effects Adverse events associated with TriCor include but are not limited to the following: Abnormal liver tests increased AST increased ALT increased CPK rhinitis Clinical Trial Results TriCor mg per day was evaluated in four randomized, placebo-controlled, double-blind, parallel-group trials as a therapy for hypercholesterolemia and mixed dyslipidemia.
Ask the Experts: ClinicalTrials.
0コメント